2-(2-Propylamino-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole → 2-(2-Propylamino-5-aminophenyl)-5-(2-benzofuranyl)benzoxazole

HRID 722654Notes

Reaction equation

HRID 722654 reaction equation
[CH2:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:6]=1[C:14]1[O:15][C:16]2[CH:22]=[CH:21][C:20]([C:23]3[O:24][C:25]4[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=4[CH:27]=3)=[CH:19][C:17]=2[N:18]=1)[CH2:2][CH3:3]>[Zn]>[CH2:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[C:14]1[O:15][C:16]2[CH:22]=[CH:21][C:20]([C:23]3[O:24][C:25]4[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=4[CH:27]=3)=[CH:19][C:17]=2[N:18]=1)[CH2:2][CH3:3]

Participants

3

Reactant 1

HCID 218843282-(2-Propylamino-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole

Product 1

HCID 218846182-(2-Propylamino-5-aminophenyl)-5-(2-benzofuranyl)benzoxazole

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

Prepared by the method of Example 47b), from 2-(2-propylamino-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole (190 mg, 0.46 mmol) and zinc (300 mg, 4.6 mmol) the subtitle compound was obtained (150 mg, 85%). The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-4448fa2a916f4fce8d80e257b7a3f86d
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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