反应详情

温度

0 °C

To a solution of benzylmagnesium chloride (20 mL, 20 mmol) in THF at −78° C. is added dropwise a 0° C. solution of 3-allyloxycarbonylamino-4-oxo-butyric acid tert-butyl ester, 102, (5.14 g, 20 mmol) in THF (100 mL). Once the addition is complete, the solution is allowed to warm to 0° C. over 30 minutes then the reaction mixture is poured into a beaker of crushed ice. The solution is extracted ×3 with CH2Cl2 (100 mL), the organic layers combined, dried over Na2SO4 and concentrated in vacuo to afford the desired product which is used without further purification.

1. additionOnce the addition
2. additionthe reaction mixture is poured into a beaker of crushed ice
3. extractionThe solution is extracted ×3 with CH2Cl2 (100 mL)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo