反应详情

温度

0 °C

To a cold (0° C.) solution of (S)-2-amino-1-butanol (2.0 g, 22.5 mmol) in acetone/H2O 1:1 (50 mL), Na2CO3 (8.7 g, 81.9 mmol) and BnOCOCl (5.8 g, 33.8 mmol) were added. After stirring at 0° C. for 1 h, the solid was filtered off and washed with acetone (2×30 mL). The filtrates were concentrated in vacuo and the residue was purified by column chromatography on silica (100% CH2Cl2 to CH2Cl2/MeOH 20:1) to obtain alcohol 7 as a white solid (2.14 g, 43% yield).

1. filtrationthe solid was filtered off
2. washwashed with acetone (2×30 mL)
3. concentrationThe filtrates were concentrated in vacuo
4. customthe residue was purified by column chromatography on silica (100% CH2Cl2 to CH2Cl2/MeOH 20:1)