反应详情

温度

0 °C

To a cold (0° C.) suspension of LiAlH4 (184 mg, 4.84 mmol) in THF (10 mL), a solution of ester 9 (375 mg, 0.97 mmol) in THF (2.5 mL) was added. The mixture was stirred at 0° C. for 2 h, and then quenched by dropwise addition of EtOH (3 ml). Na—K tartrate solution (10% aq, 30 mL) was added, and the crude was extracted with EtOAc (3×30 mL), dried over Na2SO4, concentrated in vacuo and purified by column chromatography on silica (hexane/EtOAc 5:1) to obtain alcohol 10 as a colorless oil (170 mg, 62% yield).

1. customquenched by dropwise addition of EtOH (3 ml)
2. additionNa—K tartrate solution (10% aq, 30 mL) was added
3. extractionthe crude was extracted with EtOAc (3×30 mL)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo
6. custompurified by column chromatography on silica (hexane/EtOAc 5:1)