Hydrochloric Acid → HCID 86760299, compound

HRID 722805Notes

Reaction equation

HRID 722805 reaction equation
[NH2:1][C@H:2]([C@H:4]([OH:18])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:3].[ClH:19]>O1CCOCC1>[ClH:19].[NH2:1][C@H:2]([C@H:4]([OH:18])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9899861HCID 9899861, compound

Product 1

HCID 86760299HCID 86760299, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of amine 34 (26 mg, 0.10 mmol) in dioxane (0.5 mL), anhydrous HCl solution in dioxane (5.3M, 0.38 mL, 2.02 mmol) was added. After stirring at room temperature for 5 h, the solvent was removed in vacuo. The resulting solid was washed with dioxane to obtain hydrochloride 35 as a white solid (19 mg, 64% yield).

Workup

  1. customthe solvent was removed in vacuo
  2. washThe resulting solid was washed with dioxane

Sources & evidence

ORD record
ord-2184e30253574145a619c47fb7e116a6
Source dataset
uspto-grants-2006_11
Patent number
US07138547B2

Reaction notes

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