HCID 21887305, compound → HCID 21887952, compound

HRID 722967Notes

Reaction equation

HRID 722967 reaction equation
[ClH:1].C([N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][C:9]([C:15](=[O:31])[CH2:16][CH2:17][CH2:18][CH2:19][N:20]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:30])[CH3:21])=[CH:10][CH:11]=2)[CH2:6]1)(=O)C>Cl>[ClH:30].[ClH:1].[Cl:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[CH2:23][CH2:22][N:20]([CH3:21])[CH2:19][CH2:18][CH2:17][CH2:16][C:15]([C:9]1[CH:8]=[C:7]2[C:12]([CH2:13][CH2:14][NH:5][CH2:6]2)=[CH:11][CH:10]=1)=[O:31]

Participants

3

Reactant 1

HCID 21887305HCID 21887305, compound

Product 1

HCID 21887952HCID 21887952, compoundYield 170%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of (1-(2-acetyl-1,2,3,4-tetrahydro-7-isoquinolinyl)-5-[[2-(2-chlorophenyl)ethyl](methyl)amino]-1-pentanone (5.0 g) obtained in Example 214 in concentrated hydrochloric acid (150 ml) was stirred at 130° C. for 2 hours, and the solvent of the reaction mixture was evaporated under reduced pressure to give the crude product of the title compound as a pale yellow solid (4.2 g). Further recrystallization from ethanol-diethyl ether afforded the title compound as colorless crystals having a melting point of 95° C. (dec).

Workup

  1. customthe solvent of the reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c7abcfc4750846edb829f48ea331786a
Source dataset
uspto-grants-2006_11
Patent number
US07138533B2

Reaction notes

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