Hydrogen Bromide → 8-(5-{[2-(2-Chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2 (1H)-one hydrobromide

HRID 722978Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17].[BrH:31]>>[BrH:31].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 21887313HCID 21887313, compound

Product 1

HCID 218878558-(5-{[2-(2-Chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2 (1H)-one hydrobromide

Procedure

Using 8-(5-{[2-(2-chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one hydrochloride (205 mg, 0.5 mmol) obtained in Example 39 and 48% hydrobromic acid (84 mg, 0.5 mmol) according to the same method as that of Example 360, the title compound was obtained as colorless crystals (220 mg) having a melting point of 201 to 203° C. (dec). elementary analysis as C24H27ClN2O2.HBr calculation value: C, 58.61; H, 5.74; N, 5.70. experimental value: C, 58.54; H, 5.85; N, 5.53.

Sources & evidence

ORD record: ord-0597f6f5095d4b2a97b6a0acab68af5a
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138533B2

Reaction notes

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