反应详情

温度

125 °C

Starting material C (prepared according to the above, 140 mg, 0.53 mmol) was added to a mixture of dry dimethyl sulfoxide (1 ml), dry toluene (1 ml), and piperazine (140 mg, 1.6 mmol). The stirred solution was then heated at 125° C. under nitrogen for 5 h and cooled to room temperature. Then distilled water (2 ml) was added, while the temperature is kept below 25° C. After stirring at 5° C. for 30 minute, the suspension was cooled overnight and the solid D was filtered, washed with chilled water, and dried at 70° C. under reduced pressure; yield 69%.

1. customprepared
2. temperaturecooled to room temperature
3. customis kept below 25° C
4. temperaturethe suspension was cooled overnight
5. filtrationthe solid D was filtered
6. washwashed with chilled water
7. customdried at 70° C. under reduced pressure