Lithium Hydroxide → 4-[3-methyl-2-[3-[5-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-2-methylsulfanylthiophen-3-yl]sulfonylphenyl]anilino]-4-oxobutanoic acid

HRID 723096Notes

Reaction equation

HRID 723096 reaction equation
C([O:3][C:4](=[O:43])[CH2:5][CH2:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:11]=1[C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([S:23]([C:26]2[CH:30]=[C:29]([C:31]([NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])=[NH:32])[S:28][C:27]=2[S:41][CH3:42])(=[O:25])=[O:24])[CH:18]=1)=[O:8])C.[Li+].[OH-]>CO>[C:37]([O:36][C:34]([NH:33][C:31](=[NH:32])[C:29]1[S:28][C:27]([S:41][CH3:42])=[C:26]([S:23]([C:19]2[CH:18]=[C:17]([C:11]3[C:12]([CH3:16])=[CH:13][CH:14]=[CH:15][C:10]=3[NH:9][C:7](=[O:8])[CH2:6][CH2:5][C:4]([OH:43])=[O:3])[CH:22]=[CH:21][CH:20]=2)(=[O:25])=[O:24])[CH:30]=1)=[O:35])([CH3:40])([CH3:38])[CH3:39]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 145857693ethyl 4-[3-methyl-2-[3-[5-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-2-methylsulfanylthiophen-3-yl]sulfonylphenyl]anilino]-4-oxobutanoate

Product 1

HCID 1458576434-[3-methyl-2-[3-[5-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]-2-methylsulfanylthiophen-3-yl]sulfonylphenyl]anilino]-4-oxobutanoic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-{3′-[5-(tert-Butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-succinamic acid ethyl ester (Example 133: step a) and LiOH were dissolved into MeOH and stirred at RT for 2 hours. The solvents were removed in vacuo yielding the title compound that was used with out further purification or characterization.

Workup

  1. customThe solvents were removed in vacuo

Sources & evidence

ORD record
ord-d3d7a553c71644a68acf0db71b2a907c
Source dataset
uspto-grants-2006_11
Patent number
US07138530B2

Reaction notes

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