Lithium Hydroxide → HCID 145857665, compound

Participants

Reaction Steps

The procedure as in Example 278: step e was followed using 6-{3-[3′-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-2-(4-methanesulfonyl-butyrylamino)-6-methyl-biphenyl-4-yl]-ureido}-hexanoic acid ethyl ester (48 mg, 54.3 μmol, Example 279: step a) in a MeOH/H2O (2:1) solution and 4N LiOH (54.3 μL, 0.217 mmol). The crude was taken on directly to the next step. ESI-MS (m/z): Calcd. for C36H47N5O10S4: 838.2 (M+1); found: 837.8.

Provenance & Evidence