Lithium Hydroxide → HCID 145857665, compound

HRID 723220Notes

Reaction equation

HRID 723220 reaction equation
C([O:3][C:4](=[O:57])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][NH:10][C:11]([NH:13][C:14]1[CH:19]=[C:18]([CH3:20])[C:17]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([S:27]([C:30]3[CH:34]=[C:33]([C:35]([NH:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])=[NH:36])[S:32][C:31]=3[S:45][CH3:46])(=[O:29])=[O:28])[CH:22]=2)=[C:16]([NH:47][C:48](=[O:56])[CH2:49][CH2:50][CH2:51][S:52]([CH3:55])(=[O:54])=[O:53])[CH:15]=1)=[O:12])C.[Li+].[OH-]>CO.O>[C:41]([O:40][C:38]([NH:37][C:35](=[NH:36])[C:33]1[S:32][C:31]([S:45][CH3:46])=[C:30]([S:27]([C:23]2[CH:22]=[C:21]([C:17]3[C:18]([CH3:20])=[CH:19][C:14]([NH:13][C:11](=[O:12])[NH:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4]([OH:57])=[O:3])=[CH:15][C:16]=3[NH:47][C:48](=[O:56])[CH2:49][CH2:50][CH2:51][S:52]([CH3:55])(=[O:53])=[O:54])[CH:26]=[CH:25][CH:24]=2)(=[O:28])=[O:29])[CH:34]=1)=[O:39])([CH3:44])([CH3:42])[CH3:43]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 145857636HCID 145857636, compound

Product 1

HCID 145857665HCID 145857665, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

The procedure as in Example 278: step e was followed using 6-{3-[3′-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-2-(4-methanesulfonyl-butyrylamino)-6-methyl-biphenyl-4-yl]-ureido}-hexanoic acid ethyl ester (48 mg, 54.3 μmol, Example 279: step a) in a MeOH/H2O (2:1) solution and 4N LiOH (54.3 μL, 0.217 mmol). The crude was taken on directly to the next step. ESI-MS (m/z): Calcd. for C36H47N5O10S4: 838.2 (M+1); found: 837.8.

Sources & evidence

ORD record
ord-4b7cd09b24294c4cbb42d03c4d49c256
Source dataset
uspto-grants-2006_11
Patent number
US07138530B2

Reaction notes

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