Acetic Anhydride → HCID 12361632, compound

HRID 723278Notes

Reaction equation

HRID 723278 reaction equation
[N:1]1([CH2:6][CH2:7][OH:8])[CH:5]=[CH:4][N:3]=[CH:2]1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([O:8][CH2:7][CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 74168N-(2-Hydroxyethyl)imidazole

Product 1

HCID 12361632HCID 12361632, compoundYield 85.1%

Procedure

In a nitrogen atmosphere, a mixture of 112 g of 2-(1H-imidazol-1-yl)ethanol, synthesized in Synthesis Example 1, and 122 g of acetic anhydride was stirred at room temperature for 16 hours. The reaction mixture was subjected to conventional aqueous work-up and then purified by vacuum distillation, obtaining 131 g of 2-(1H-imidazol-1-yl)ethyl acetate (boiling point 102° C./27 Pa, yield 85%).

Workup

  1. distillationpurified by vacuum distillation

Sources & evidence

ORD record
ord-6badd93e79964396b50b92c4e72e94b2
Source dataset
uspto-grants-2006_11
Patent number
US07141351B2

Reaction notes

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