Methyl Acrylate → HCID 21872504, compound

HRID 723281Notes

Reaction equation

HRID 723281 reaction equation
[C:1]1([C:7]2[NH:8][CH:9]=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:12]([O:16][CH3:17])(=[O:15])[CH:13]=[CH2:14]>CO>[C:1]1([C:7]2[N:11]([CH2:14][CH2:13][C:12]([O:16][CH3:17])=[O:15])[CH:10]=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 695912-Phenylimidazole

Product 1

HCID 21872504HCID 21872504, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 144 g of 2-phenylimidazole, 103 g of methyl acrylate and 500 g of methanol was heated and stirred at 60° C. for 20 hours. The solvent was distilled off in vacuo. Purification by column chromatography gave 193 g of methyl 3-(2-phenyl-1H-imidazol-1-yl)propionate (yield 84%).

Workup

  1. temperaturewas heated
  2. distillationThe solvent was distilled off in vacuo
  3. customPurification by column chromatography

Sources & evidence

ORD record
ord-8755cabc790042f094b1e365b2f3576f
Source dataset
uspto-grants-2006_11
Patent number
US07141351B2

Reaction notes

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