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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 723293Generated: October 29, 2026

Benzimidazole → 2-(1H-Benzimidazol-1-yl)ethan-1-ol

https://huagongshe.com/reaction/723293

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzimidazoleHCID 5798—
ReactantEthylene OxideHCID 6354—
SolventDimethylacetamideHCID 31374—
Product2-(1H-Benzimidazol-1-yl)ethan-1-olHCID 228131—

Reaction Conditions

Temperature100 °C

Reaction Steps

A mixture of 118 g of benzimidazole, 48.5 g of ethylene oxide, and 400 g of N,N-dimethylacetamide was heated and stirred in an autoclave at 100° C. for 16 hours. The solvent was distilled off in vacuo, yielding crude 2-(1H-benzimidazol-1-yl)ethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07141352B2
Source datasetuspto-grants-2006_11
ORD IDord-ccffdb8177254b2187394e72c2d6be8b
Source noteuspto-grants-2006_11