Benzimidazole → 2-(1H-Benzimidazol-1-yl)ethan-1-ol

HRID 723293Notes

Reaction equation

HRID 723293 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][CH:2]=1.[CH2:10]1[O:12][CH2:11]1>CN(C)C(=O)C>[N:1]1([CH2:10][CH2:11][OH:12])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 5798BenzimidazoleHCID 6354Ethylene Oxide

Product 1

HCID 2281312-(1H-Benzimidazol-1-yl)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 118 g of benzimidazole, 48.5 g of ethylene oxide, and 400 g of N,N-dimethylacetamide was heated and stirred in an autoclave at 100° C. for 16 hours. The solvent was distilled off in vacuo, yielding crude 2-(1H-benzimidazol-1-yl)ethanol.

Workup

  1. temperaturewas heated
  2. distillationThe solvent was distilled off in vacuo

Sources & evidence

ORD record
ord-ccffdb8177254b2187394e72c2d6be8b
Source dataset
uspto-grants-2006_11
Patent number
US07141352B2

Reaction notes

Loading…