Hydrogen Bromide → HCID 178526408, compound

HRID 723322Notes

Reaction equation

HRID 723322 reaction equation
Br.C[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[N+:14]([O-:16])=[O:15])[N:10]=[CH:9][NH:8][C:7]2=[O:17]>CC(O)=O>[N+:14]([C:13]1[CH:12]=[C:11]2[C:6]([C:7]([OH:17])=[N:8][CH:9]=[N:10]2)=[CH:5][C:4]=1[OH:3])([O-:16])=[O:15]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 1354520046-Methoxy-7-nitroquinazolin-4(3H)-one

Product 1

HCID 178526408HCID 178526408, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution containing 20 ml of 48% aqueous HBr and 20 ml of AcOH was added 6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one (1.4 g, 6.3 mmol) and the mixture was refluxed overnight. The resulting solution was evaporated to afford the crude phenol as a residue and was used without further purification (1.2 g, 5.8 mmol) (M+1, 208).

Workup

  1. temperaturethe mixture was refluxed overnight
  2. customThe resulting solution was evaporated

Sources & evidence

ORD record
ord-3797bd52a102409ab16be5f3345852ab
Source dataset
uspto-grants-2006_11
Patent number
US07141565B1

Reaction notes

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