4-Fluorobenzyl bromide → 3-[4-(4-Fluoro-benzyloxy)-phenyl]-5-(4-methyl-imidazol-1-ylmethyl)-isoxazole

HRID 72334Notes

Reaction equation

HRID 72334 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][N:5]([CH2:7][C:8]2[O:12][N:11]=[C:10]([C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)[CH:9]=2)[CH:6]=1.[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Br)=[CH:23][CH:22]=1>>[F:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25][O:19][C:16]2[CH:17]=[CH:18][C:13]([C:10]3[CH:9]=[C:8]([CH2:7][N:5]4[CH:6]=[C:2]([CH3:1])[N:3]=[CH:4]4)[O:12][N:11]=3)=[CH:14][CH:15]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 136359910HCID 136359910, compound

Product 1

HCID 666176843-[4-(4-Fluoro-benzyloxy)-phenyl]-5-(4-methyl-imidazol-1-ylmethyl)-isoxazole

Procedure

An experiment was performed in the same manner as in Example 139 to synthesize 4-[5-(4-methyl-imidazol-1-ylmethyl)-isoxazol-3-yl]-phenol as an intermediate, and then a synthesis was performed using 4-fluorobenzyl bromide in the same manner as in Example 142.

Sources & evidence

ORD record
ord-2e4270bcc4dd4134a7682e3898641c9e
Source dataset
uspto-grants-2014_09
Patent number
US08828992B2

Reaction notes

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