1,1'-Carbonyldiimidazole → HCID 21873424, 화합물

HRID 723351노트

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HRID 723351 반응식
[C:1](N1C=CN=C1)(N1C=CN=C1)=[O:2].[CH3:13][N:14]([CH3:25])[CH2:15][CH2:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][CH:19]=1.[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([NH:40][CH2:41][CH:42]([O:45][CH3:46])[O:43][CH3:44])=[CH:36][CH:35]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>CN(C)C=O>[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([N:40]([CH2:41][CH:42]([O:45][CH3:46])[O:43][CH3:44])[C:1]([NH:24][C:21]2[CH:22]=[CH:23][C:18]([O:17][CH2:16][CH2:15][N:14]([CH3:25])[CH3:13])=[CH:19][CH:20]=2)=[O:2])=[CH:36][CH:35]=1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

참가 물질

5

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HCID 682631,1'-CarbonyldiimidazoleHCID 64846554-[2-(Dimethylamino)ethoxy]anilineHCID 21873334HCID 21873334, 화합물

생성물 1

HCID 21873424HCID 21873424, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
80 °C

실험 절차

Carbonyldiimidazole (2.7 g) was added to a solution of 4-(2-dimethylaminoethoxy)phenylamine (3.01 g) in dimethylformamide (40 mL) cooled in ice. After 30 minutes, (4-benzyloxyphenyl)-(2,2-dimethoxyethyl)amine (4.8 g) was added, and the mixture was heated at 80° C. for 30 minutes. After cooling, volatiles were removed and the residue was purified by MPLC (eluent: heptane/ethyl acetate 9:1). The product with the molecular weight of 493.61 (C28H35N3O5); MS (ESI): 494 ([M+H]+), was obtained in this way.

후처리

  1. temperaturecooled in ice
  2. temperatureAfter cooling
  3. customvolatiles were removed
  4. customthe residue was purified by MPLC (eluent: heptane/ethyl acetate 9:1)
  5. customMS (ESI): 494 ([M+H]+), was obtained in this way

출처 및 근거

ORD 기록
ord-b3f283fe8665466eba1401cbb6fbca90
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07141561B2

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