1,1'-Carbonyldiimidazole → HCID 21873424, compound

Participants

Reaction Conditions

Reaction Steps

Carbonyldiimidazole (2.7 g) was added to a solution of 4-(2-dimethylaminoethoxy)phenylamine (3.01 g) in dimethylformamide (40 mL) cooled in ice. After 30 minutes, (4-benzyloxyphenyl)-(2,2-dimethoxyethyl)amine (4.8 g) was added, and the mixture was heated at 80° C. for 30 minutes. After cooling, volatiles were removed and the residue was purified by MPLC (eluent: heptane/ethyl acetate 9:1). The product with the molecular weight of 493.61 (C28H35N3O5); MS (ESI): 494 ([M+H]+), was obtained in this way.

Provenance & Evidence