Trifluoroacetic acid → N-{4-[2-oxo-3-(4-phenoxyphenyl)-2,3-dihydroimidazol-1-yl]phenyl}acetamide

Participants

Reaction Steps

4-Acetaminoaniline was reacted with carbonyidiimidazole and (2,2-dimethoxyethyl)-(4-phenoxyphenyl)amine as described in example 92, followed by treatment of the crude product with trifluoroacetic acid at 80° C. The product is precipitated on addition of ethyl acetate/heptane 1:1. The precipitated solid was filtered off and dried in a vacuum oven at 40° C. The product with the molecular weight of 385.43 (C23H17N3O2); MS (ESI): 386 ([M+H]+) was obtained in this way.

Provenance & Evidence