HCID 21873953, compound → HCID 21873942, compound

HRID 723378Notes

Reaction equation

HRID 723378 reaction equation
[NH2:1][C:2]1[C:3]2[N:4]([C:18]([CH3:22])=[C:19]([CH3:21])[N:20]=2)[CH:5]=[CH:6][C:7]=1[C:8](=[O:17])[CH:9]1[O:16][CH:10]1[C:11]1[CH:15]=[CH:14][S:13][CH:12]=1>FC(F)(F)C(O)C(F)(F)F>[OH:16][CH:9]1[C:8](=[O:17])[C:7]2[CH:6]=[CH:5][N:4]3[C:18]([CH3:22])=[C:19]([CH3:21])[N:20]=[C:3]3[C:2]=2[NH:1][CH:10]1[C:11]1[CH:15]=[CH:14][S:13][CH:12]=1

Participants

3

Reactant 1

HCID 21873953HCID 21873953, compound

Product 1

HCID 21873942HCID 21873942, compoundYield 6.4%

Reagents, catalysts & solvents 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanolSolvent

Procedure

1.1 g of 8-amino-7-[2,3-epoxy-1-oxo-3-(3-thienyl)propyl]-2,3-dimethylimidazo[1,2-a]pyridine are dissolved in 20 ml of hexafluoroisopropanol at room temperature, the solvent is stripped off after 19 hours and the residue is purified on silica gel (eluent: methylene chloride/methanol=100/3). 70 mg of the title compound of m.p. 222–25° C. (diethyl ether) are obtained.

Workup

  1. customthe residue is purified on silica gel (eluent: methylene chloride/methanol=100/3)

Sources & evidence

ORD record
ord-06ae188f6cb04c248b8462601c495ce9
Source dataset
uspto-grants-2006_11
Patent number
US07141567B2

Reaction notes

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