Nitric Acid → HCID 21873584, compound

HRID 723507Notes

Reaction equation

HRID 723507 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[N+:11]([O-])(O)=O>C(O)(=O)C.C(O)C.[Pd]>[NH2:11][C:7]1[C:8]([OH:10])=[CH:9][C:2]([F:1])=[C:3]([CH:6]=1)[C:4]#[N:5]

Participants

6

Reactant 2

HCID 944Nitric AcidHCID 27346752-Fluoro-4-hydroxybenzonitrile

Product 1

HCID 21873584HCID 21873584, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 702EthanolSolvent

Procedure

This was prepared from 2-fluoro-4-hydroxy-benzonitrile by nitration (concentrated nitric acid in acetic acid at 40° C.) followed by hydrogenation in ethanol over 10% palladium/carbon.

Sources & evidence

ORD record
ord-f23d48f167c24968b9ca170a9adeb4a3
Source dataset
uspto-grants-2006_11
Patent number
US07141564B2

Reaction notes

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