反应详情

A solution of ethyl 2-hydroxy-6-methylbenzoic acid (4.56 g, 25.3 mmol) and diisopropylethylamine (13.2 mL, 76 mmol) in dry dichloromethane (30 mL) was cooled in an ice-bath. Chloromethyl methyl ether (3.83 mL, 50.6 mmol) was added slowly and the mixture was allowed to stand at 0° C., warming slowly to room temperature. After 36 hours a further portion of chloromethyl methyl ether (1.9 mL) was added and the mixture was left at room temperature overnight. The mixture was then washed with 10% citric acid, water and brine, dried and evaporated to give the title compound (6.34 g, 100%).

1. customto stand at 0° C.
2. washThe mixture was then washed with 10% citric acid, water and brine
3. customdried
4. customevaporated