反应详情

To a solution methyl 6-amino-5-bromopyridine-2-carboxylate (20.04 g) in acetic acid (900 ml) was added N-chlorosuccinimide (13.96 g) and the resultant solution was heated to 120° C. for 1 hour. The solution was then evaporated and treated with excess aqueous sodium bicarbonate and extracted with dichloromethane. The organic fraction was dried and evaporated to give the product (21.98 g).

1. customThe solution was then evaporated
2. additiontreated with excess aqueous sodium bicarbonate
3. extractionextracted with dichloromethane
4. customThe organic fraction was dried
5. customevaporated