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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 723539Generated: October 29, 2026

Phosphorus tribromide → 4-Bromo-6,8-difluoroquinoline

https://huagongshe.com/reaction/723539

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus tribromideHCID 24614—
ReactantHCID 178516459HCID 178516459—
SolventDimethylformamideHCID 6228—
Product4-Bromo-6,8-difluoroquinolineHCID 16111714—

Reaction Steps

This was prepared from 4-hydroxy-6,8-difluoro-quinoline by heating with phosphorus tribromide in dimethylformamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07141564B2
Source datasetuspto-grants-2006_11
ORD IDord-b9f0565738b84e0caf05ac3dd3ebefed
Source noteuspto-grants-2006_11