Phosphorus tribromide → 4-Bromo-6,8-difluoroquinoline

HRID 723539Notes

Reaction equation

HRID 723539 reaction equation

O[C:2]1[C:11]2[C:6](=[C:7]([F:13])[CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:15]>CN(C)C=O>[Br:15][C:2]1[C:11]2[C:6](=[C:7]([F:13])[CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24614Phosphorus tribromide

HCID 178516459HCID 178516459, compound

Product 1

HCID 161117144-Bromo-6,8-difluoroquinoline

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This was prepared from 4-hydroxy-6,8-difluoro-quinoline by heating with phosphorus tribromide in dimethylformamide.

Sources & evidence

ORD record: ord-b9f0565738b84e0caf05ac3dd3ebefed
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141564B2

Reaction notes

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