HCID 21876726, compound → HCID 21876572, compound

HRID 723747Notes

Reaction equation

HRID 723747 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=3[F:20])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([N:8]2[CH2:9][CH2:10][C:5]3([O:1][CH2:2][CH2:3][O:4]3)[CH2:6][CH2:7]2)=[C:12]([F:20])[CH:13]=1

Participants

4

Reactant 1

HCID 21876726HCID 21876726, compound

Product 1

HCID 21876572HCID 21876572, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

4-(1,4-Dioxa-8-azaspiro[4,5]dec-8-yl)-3-fluoronitrobenzene (24.48 g, 0.087 M) was dissolved in ethyl acetate (500 ml) treated with palladium catalyst (10% on carbon, 5 g) and hydrogenated at atmospheric pressure until the theoretical uptake of gas. After filtration through celite and evaporation, the required product was obtained as a pink solid of sufficient quality for use without purification (19.3 g).

Workup

  1. filtrationAfter filtration
  2. customthrough celite and evaporation

Sources & evidence

ORD record
ord-d7cd1421aa274b3faed1f5bf071a4bf3
Source dataset
uspto-grants-2006_11
Patent number
US07141583B2

Reaction notes

Loading…