Hydrochloric Acid → HCID 69362923, compound

HRID 723759Notes

Reaction equation

HRID 723759 reaction equation
C(OC([NH:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][N:26]4[CH:30]=[CH:29][N:28]=[N:27]4)[O:22][C:21]3=[O:31])=[CH:16][C:15]=2[F:32])[CH2:10]1)=O)(C)(C)C.Cl>ClCCl.C(O)C>[NH2:8][C@@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:24][C@H:23]([CH2:25][N:26]4[CH:30]=[CH:29][N:28]=[N:27]4)[O:22][C:21]3=[O:31])=[CH:16][C:15]=2[F:32])[CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 69363436HCID 69363436, compound

Product 1

HCID 69362923HCID 69362923, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

(5R)-3-(4-((3R)-3-(t-Butoxycarbonyl)aminopyrrolidin-1-yl)-3-fluorophenyl)-5-(1,2,3-triazol-1-ylmethyl)oxazolidin-2-one (532 mg, 1.2 mM), was dissolved in dichloromethane (10 ml), and treated with a solution of hydrogen chloride in ethanol (3.8M, 2 ml). After stirring 4 hours at ambient temperature, the precipitated hydrochloride of the product (230 mg) was filtered, and the filtrate diluted with diethyl ether to deposit more product (218 mg).

Workup

  1. filtrationthe precipitated hydrochloride of the product (230 mg) was filtered
  2. additionthe filtrate diluted with diethyl ether

Sources & evidence

ORD record
ord-7e62cc9a17bf4be895321ad80fa0118d
Source dataset
uspto-grants-2006_11
Patent number
US07141583B2

Reaction notes

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