Ammonium Chloride → 6-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

HRID 723930Notes

Reaction equation

HRID 723930 reaction equation
[CH2:1]([N:3]1[C:7]2[C:8]([F:15])=[CH:9][C:10]([N+:12]([O-])=O)=[CH:11][C:6]=2[O:5][C:4]1=[O:16])[CH3:2].[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:12][C:10]1[CH:9]=[C:8]([F:15])[C:7]2[N:3]([CH2:1][CH3:2])[C:4](=[O:16])[O:5][C:6]=2[CH:11]=1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 45095618HCID 45095618, compound

Product 1

HCID 684905716-amino-3-ethyl-4-fluoro-1,3-benzoxazol-2(3H)-one

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Prepared from 3-ethyl-4-fluoro-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 1.05 g, 4.90 mmol), ammonium chloride (2.62 g, 49 mmol) and iron powder (1.09 g, 19.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.95 g, 99%).

Sources & evidence

ORD record
ord-b1e027837eee4e939171e5e333bd359e
Source dataset
uspto-grants-2006_11
Patent number
US07141588B2

Reaction notes

Loading…