反应详情

A suspension of 1-(2-amino-benzothiazol-6-yl)-3-benzoyl-thiourea (Example 2, 0.2 g, 0.61 mmol) and 2.0 N NaOH (0.67 mL, 1.34 mmol) in 10 mL of THF was heated at reflux for 4 hours. Upon cooling, a yellow solid precipitated which was filtered. Yield: 66.5%, 1H-NMR (DMSO-d6): δ 9.55 (s, 1H); 7.64 (d, 1H, J=1.8 Hz); 7.44 (s, 2H); 7.27 (m, 2H); 7.03 (dd, 1H, J=8.0, 2.0 Hz).

1. temperaturewas heated
2. temperatureat reflux for 4 hours
3. temperatureUpon cooling
4. customa yellow solid precipitated which
5. filtrationwas filtered