N-(2-Amino-1,3-benzothiazol-5-yl)thiourea → N-(2-Amino-benzothiazol-5-yl)-thiophene-2-carboxamidine hydrobromide

関与物質

反応手順

To a solution of the amino urea compound (Example 18, 35 mg, 0.21 mmol) in ethanol (1.4 mL) was added thiophene-2-carboximidothioic acid phenyl ester hydrobromide (63.7 mg, 0.21 mmol). The mixture was stirred at room temperature for 17 hours and then diluted with diethyl ether. The light yellow precipitate was collected by filtration (64.8 mg, 93%). 1H-NMR (DMSO d6) δ: 11.36 (br s, 1H), 9.72 (br s, 1H), 8.83 (br s, 1H), 8.17 (d, 1H, J=4.68 Hz).

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