N-(2-Amino-1,3-benzothiazol-5-yl)thiourea → N-(2-Amino-benzothiazol-5-yl)-thiophene-2-carboxamidine hydrobromide

HRID 723954Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 723954
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH2:14])=S)=[CH:7][C:5]=2[N:6]=1.[BrH:15].C1(SC([C:25]2[S:26][CH:27]=[CH:28][CH:29]=2)=N)C=CC=CC=1>C(O)C.C(OCC)C>[BrH:15].[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][C:8]([NH:11][C:12]([C:25]3[S:26][CH:27]=[CH:28][CH:29]=3)=[NH:14])=[CH:7][C:5]=2[N:6]=1

Komponenten

5

Edukt 2

HCID 10263051N-(2-Amino-1,3-benzothiazol-5-yl)thioureaHCID 66912440Thiophene-2-carboximidothioic acid phenyl ester hydrobromide

Produkt 1

HCID 178419711N-(2-Amino-benzothiazol-5-yl)-thiophene-2-carboxamidine hydrobromide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of the amino urea compound (Example 18, 35 mg, 0.21 mmol) in ethanol (1.4 mL) was added thiophene-2-carboximidothioic acid phenyl ester hydrobromide (63.7 mg, 0.21 mmol). The mixture was stirred at room temperature for 17 hours and then diluted with diethyl ether. The light yellow precipitate was collected by filtration (64.8 mg, 93%). 1H-NMR (DMSO d6) δ: 11.36 (br s, 1H), 9.72 (br s, 1H), 8.83 (br s, 1H), 8.17 (d, 1H, J=4.68 Hz).

Aufarbeitung

  1. filtrationThe light yellow precipitate was collected by filtration (64.8 mg, 93%)

Quellen und Nachweise

ORD-Eintrag
ord-df9565d8bcfa4bdf99cfb000e15ac7e3
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07141595B2

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