反应详情

To the solution of tert-butyl (1-(4-(1H-tetrazol-5-yl)phenyl)cyclopropyl)carbamate (D16) (800 mg, 2.65 mmol) in ethylacetate (10 ml), 4N HCl/ethyl acetate solution (20 ml) was added and the mixture was stirred at room temperature for 1 hour, then cooled to 0° C. The solid was filtered and washed with ethylacetate to afford the title compound (D17) (510 mg) as a yellow solid.

1. temperaturecooled to 0° C
2. filtrationThe solid was filtered
3. washwashed with ethylacetate