Hydrogen chloride-ethyl acetate → HCID 178479016, compound

HRID 72398Notes

Reaction equation

HRID 72398 reaction equation
[NH:1]1[C:5]([C:6]2[CH:11]=[CH:10][C:9]([C:12]3([NH:15]C(=O)OC(C)(C)C)[CH2:14][CH2:13]3)=[CH:8][CH:7]=2)=[N:4][N:3]=[N:2]1.[ClH:23].C(OCC)(=O)C>C(OC(=O)C)C>[ClH:23].[NH:4]1[C:5]([C:6]2[CH:7]=[CH:8][C:9]([C:12]3([NH2:15])[CH2:13][CH2:14]3)=[CH:10][CH:11]=2)=[N:1][N:2]=[N:3]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178452605HCID 178452605, compound

Product 1

HCID 178479016HCID 178479016, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To the solution of tert-butyl (1-(4-(1H-tetrazol-5-yl)phenyl)cyclopropyl)carbamate (D16) (800 mg, 2.65 mmol) in ethylacetate (10 ml), 4N HCl/ethyl acetate solution (20 ml) was added and the mixture was stirred at room temperature for 1 hour, then cooled to 0° C. The solid was filtered and washed with ethylacetate to afford the title compound (D17) (510 mg) as a yellow solid.

Workup

  1. temperaturecooled to 0° C
  2. filtrationThe solid was filtered
  3. washwashed with ethylacetate

Sources & evidence

ORD record
ord-61eb421ae0e840aeaca65dae7176814c
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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