Isobutyryl chloride → HCID 21876134, compound

HRID 724031Notes

Reaction equation

[NH2:1][C:2]1[C:3]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][OH:20])=[CH:14][CH:13]=2)=[N:4][C:5]([CH3:10])=[C:6]([Br:9])[C:7]=1[CH3:8].[C:21](Cl)(=[O:25])[CH:22]([CH3:24])[CH3:23]>>[CH3:23][CH:22]([CH3:24])[C:21]([O:20][CH2:19][CH2:18][C:15]1[CH:16]=[CH:17][C:12]([N:11]2[C:3]3=[N:4][C:5]([CH3:10])=[C:6]([Br:9])[C:7]([CH3:8])=[C:2]3[N:1]=[C:2]2[CH:7]([CH3:8])[CH3:6])=[CH:13][CH:14]=1)=[O:25]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 21875575HCID 21875575, compound

Product 1

HCID 21876134HCID 21876134, compound

Procedure

The title compound was prepared according to the procedure described in step 5 of Example 1 from 2-{4-[(3-amino-5-bromo-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethanol (step 4) and isobutyryl chloride.

Sources & evidence

ORD record: ord-cb3eafd06bf84345b2748604bd4de9e1
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141580B2

Reaction notes

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