反应详情

To an ice cooled solution of tert-butyl 3-(methoxy(methyl)carbamoyl)azetidine-1-carboxylate (D26) (61.8 mg, 0.25 mmol) in dry tetrahydrofuran (2 ml), 3-Fluorophenylmagnesiumbromide (1M in tetrahyfrofuran) (0.506 ml, 0.506 mmol) was added dropwise the under stirring under N2 atmosphere. The reaction mixture was stirred at room temperature for 1 h then NH4Cl sat. sol. (10 ml) was added and the mixture was extracted with ethylacetate (3×20 ml). The organic layers were collected, dried with Na2SO4 and filtrated. The solvent was evaporated in vacuo to afford the title compound (D27) (69 mg).

1. stirringThe reaction mixture was stirred at room temperature for 1 h
2. extractionthe mixture was extracted with ethylacetate (3×20 ml)
3. customThe organic layers were collected
4. dry with materialdried with Na2SO4
5. filtrationfiltrated
6. customThe solvent was evaporated in vacuo