HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Difluoroaniline → Tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Difluoroaniline | HCID 9709 | — |
| Reactant | 3-Oxo-azetidine-1-carboxylic acid tert-butyl ester | HCID 1519404 | — |
| Product | Tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylate | HCID 63303164 | 18.1% |
Reaction Steps
The title compound (D31) (90 mg) was prepared according to the experimental procedure described in Description 30 starting from 1-Boc-3-azetidinone (300 mg, 1.75 mmol) and 2,4-difluoroaniline (0.178 ml, 1.75 mmol). Reaction time: 1 week.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08828987B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-571fdbfbb6aa41e1b72cc0c12f5d4049 |
| Source note | uspto-grants-2014_09 |