2,4-Difluoroaniline → Tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylate

HRID 72408Notes

Reaction equation

HRID 72408 reaction equation
[C:1]([N:8]1[CH2:11][C:10](=O)[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[F:13][C:14]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:15]=1[NH2:16]>>[F:13][C:14]1[CH:20]=[C:19]([F:21])[CH:18]=[CH:17][C:15]=1[NH:16][CH:10]1[CH2:11][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9]1

Participants

3

Reactant 2

HCID 97092,4-DifluoroanilineHCID 15194043-Oxo-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 63303164Tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylateYield 18.1%

Procedure

The title compound (D31) (90 mg) was prepared according to the experimental procedure described in Description 30 starting from 1-Boc-3-azetidinone (300 mg, 1.75 mmol) and 2,4-difluoroaniline (0.178 ml, 1.75 mmol). Reaction time: 1 week.

Workup

  1. customReaction time
  2. custom1 week

Sources & evidence

ORD record
ord-571fdbfbb6aa41e1b72cc0c12f5d4049
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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