3-Oxo-azetidine-1-carboxylic acid tert-butyl ester → HCID 67958091, compound

HRID 72409Notes

Reaction equation

HRID 72409 reaction equation
[C:1]([N:8]1[CH2:11][C:10](=O)[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=1[CH3:24]>>[CH3:24][C:15]1[CH:16]=[C:17]([C:20]([F:21])([F:22])[F:23])[CH:18]=[CH:19][C:14]=1[NH:13][CH:10]1[CH2:11][N:8]([C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])[CH2:9]1

Participants

3

Reactant 2

HCID 15194043-Oxo-azetidine-1-carboxylic acid tert-butyl esterHCID 137504374-Amino-3-methylbenzotrifluoride

Product 1

HCID 67958091HCID 67958091, compoundYield 21.4%

Procedure

The title compound (D32) (330 mg) was prepared according to the experimental procedure described in Description 30 starting from 1-Boc-3-azetidinone (800 mg, 4.67 mmol) and 4-Amino-3-methylbenzotrifluoride (818.4 mg, 4.67 mmol).

Sources & evidence

ORD record
ord-dbd1b969ca3146dabb36fd51d7ef2a38
Source dataset
uspto-grants-2014_09
Patent number
US08828987B2

Reaction notes

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