2-Chloro-4,6-dimethyl-3-nitropyridine → (2S)-1-{4-[(4,6-dimethyl-3-nitro-2-pyridinyl)amino]phenyl}-2-propanol

HRID 724143Notes

Reaction equation

HRID 724143 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([CH3:11])[CH:5]=[C:4]([CH3:12])[N:3]=1.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][C@@H:21]([OH:23])[CH3:22])=[CH:16][CH:15]=1>>[CH3:11][C:6]1[CH:5]=[C:4]([CH3:12])[N:3]=[C:2]([NH:13][C:14]2[CH:15]=[CH:16][C:17]([CH2:20][C@@H:21]([OH:23])[CH3:22])=[CH:18][CH:19]=2)[C:7]=1[N+:8]([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 218755782-Chloro-4,6-dimethyl-3-nitropyridineHCID 67099494(S)-1-(4-aminophenyl)propan-2-ol

Product 1

HCID 67099429(2S)-1-{4-[(4,6-dimethyl-3-nitro-2-pyridinyl)amino]phenyl}-2-propanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 162 from 2-chloro-4,6-dimethyl-3-nitropyridine (step 2 of Example 1) and (2S)-1-(4-aminophenyl)-2-propanol (step 2 of Example 248).

Sources & evidence

ORD record
ord-46fb849066174de5bbbbdb966bc22ade
Source dataset
uspto-grants-2006_11
Patent number
US07141580B2

Reaction notes

Loading…