反应详情

To a solution of (5-amino-2-pyridinyl)acetic acid (1.46 g, 9.6 mmol, Daisley; R. W.; Hanbali, J. R., Synthetic Communications., 1981, 11 (9), 743.) in ethanol was added conc. H2SO4 and stirred for 16.5 h under hydrogen atmosphere at room temperature. The mixture was neutralized with saturated NaHCO3 aqueous solution and the solvent was removed. The mixture was diluted with water and extracted with ethyl acetate (5×20 ml). The organic layer was washed with brine, dried (MgSO4) and concentrated to give 1.2 g of title compound as brown oil.

1. customthe solvent was removed
2. additionThe mixture was diluted with water
3. extractionextracted with ethyl acetate (5×20 ml)
4. washThe organic layer was washed with brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated