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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 724159Generated: October 30, 2026

Benzyl ethyl 2-(6-nitro-3-pyridinyl)malonate → Ethyl 2-(6-nitropyridin-3-yl)acetate

https://huagongshe.com/reaction/724159

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl ethyl 2-(6-nitro-3-pyridinyl)malonateHCID 21875897—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
ProductEthyl 2-(6-nitropyridin-3-yl)acetateHCID 21300451—

Reaction Steps

To a solution of benzyl ethyl 2-(6-nitro-3-pyridinyl)malonate (5.26 g, 15.3 mmol,) in ethanol was added palladium on carbon (530 mg) and stirred for 6 h under hydrogen atmosphere at room temperature. The catalyst was filtered off through a pad of celite and the filtrate was concentrated to give a title compound as yellow brown oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07141580B2
Source datasetuspto-grants-2006_11
ORD IDord-1094822fcc2344c4b4b93dac7c158959
Source noteuspto-grants-2006_11