5,6-Dihydropyrrolo[1,2-c]imidazol-7-one → 7-(5-fluorobenzo[b]thiophen-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-ol

HRID 724220Notes

Reaction equation

HRID 724220 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]2[S:6][CH:7]=[CH:8][C:4]=2[CH:3]=1.[CH:11]1[N:15]=[CH:14][N:13]2[CH2:16][CH2:17][C:18](=[O:19])[C:12]=12>>[F:1][C:2]1[CH:10]=[CH:9][C:5]2[S:6][C:7]([C:18]3([OH:19])[C:12]4[N:13]([CH:14]=[N:15][CH:11]=4)[CH2:16][CH2:17]3)=[CH:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 111709605,6-Dihydropyrrolo[1,2-c]imidazol-7-oneHCID 118159505-Fluoro-1-benzothiophene

Product 1

HCID 99434457-(5-fluorobenzo[b]thiophen-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-olYield 34.6%

Procedure

The reaction and purification in the same manner as in Example 1 using 5-fluorobenzo[b]thiophene (0.30 g) and 5,6-dihydro-7H-pyrrolo[1,2-c]imidazol-7-one (0.18 g) afforded the title compound (0.14 g) as colorless crystals.

Sources & evidence

ORD record
ord-3b686b7144a84f608b988a51352b9256
Source dataset
uspto-grants-2006_11
Patent number
US07141598B2

Reaction notes

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