反应详情

Methyl iodide (14.67 ml, 0.235 mol) was added dropwise to a solution of 3-methoxy-benzenethiol (30 g, 0.214 mol) and potassium carbonate (29.6 g, 0.214 mol) in acetone (400 ml) under nitrogen at 3° C. The reaction was allowed to warm to room temperature and the solvent was removed under reduced pressure. The residue was diluted with water (300 ml) and the aqueous layer was extracted with diethylether (3×200 ml). The combined organic extracts were dried over MgSO4 and the solvent was removed under reduced pressure to give 1-Methoxy-3-methylsulfanyl-benzene (32.87 g) as a pale yellow liquid.

1. customthe solvent was removed under reduced pressure
2. additionThe residue was diluted with water (300 ml)
3. extractionthe aqueous layer was extracted with diethylether (3×200 ml)
4. dry with materialThe combined organic extracts were dried over MgSO4
5. customthe solvent was removed under reduced pressure