Hydrochloric Acid → 2-Amino-1-methylcyclohexanol hydrochloride

Participants

Reaction Steps

4M Hydrochloric acid in dioxan (40 ml, 160 mmol) was added to a solution of the less polar diastereoisomer of tert-butyl 2-hydroxy-2-methylcyclohexylcarbamate (875 mg, 3.82 mmol) in dioxan (5 ml). The mixture was stirred for 4 h then the solvent was removed under reduced pressure and the residue dried in vacuo to afford a single diastereoisomer of 2-amino-1-methylcyclohexanol hydrochloride (656 mg) as a white solid.

Provenance & Evidence