Hydrochloric Acid → 2-Amino-1-methylcyclohexanol hydrochloride

HRID 724262Notes

Reaction equation

HRID 724262 reaction equation
[ClH:1].[OH:2][C:3]1([CH3:17])[CH2:8][CH2:7][CH2:6][CH2:5][CH:4]1[NH:9]C(=O)OC(C)(C)C>O1CCOCC1>[ClH:1].[NH2:9][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C:3]1([CH3:17])[OH:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69571280HCID 69571280, compound

Product 1

HCID 218771592-Amino-1-methylcyclohexanol hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4M Hydrochloric acid in dioxan (40 ml, 160 mmol) was added to a solution of the less polar diastereoisomer of tert-butyl 2-hydroxy-2-methylcyclohexylcarbamate (875 mg, 3.82 mmol) in dioxan (5 ml). The mixture was stirred for 4 h then the solvent was removed under reduced pressure and the residue dried in vacuo to afford a single diastereoisomer of 2-amino-1-methylcyclohexanol hydrochloride (656 mg) as a white solid.

Workup

  1. customthe solvent was removed under reduced pressure
  2. customthe residue dried in vacuo

Sources & evidence

ORD record
ord-4e008037db354c71b864ba99463100a2
Source dataset
uspto-grants-2006_11
Patent number
US07141586B2

Reaction notes

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