反应详情

温度

150 °C

To a solution of azetidin-3-ol hydrochloride (637 mg, 5.82 mmol, commercially available from Matrix Scientific #011272) and trietylamine (1.69 ml, 12.11 mmol) in methanol (10 ml), methyl 2-chloropyridine-3-carboxylate (1 g, 4.84 mmol) was added and the mixture stirred at 150° C. under microwave irradiation 10 min (2 cycles of 5 min each). The residue obtained after solvent evaporation was purified by SPE-Si cartridge (10 g) eluting with a mixture cyclohexane/ethylacetate from 90/10 to 60/40. Collected fractions after solvent evaporation afforded the title compound (D62) (D004/099/1) (800 mg)

1. customThe residue obtained
2. customafter solvent evaporation
3. customwas purified by SPE-Si cartridge (10 g)
4. washeluting with a mixture cyclohexane/ethylacetate from 90/10 to 60/40
5. customCollected fractions after solvent evaporation