Hydrochloric Acid → HCID 21877198, compound

Participants

Reaction Steps

4M Hydrochloric acid in dioxan (13 ml, 52 mmol) was added to a solution of the more polar diastereoisomer of tert-butyl 4-[(3-hydroxy-2,2-dimethylpropanoyl)amino]cyclohexylcarbamate (840 g, 2.67 mmol) in dioxan (5 ml). The mixture was stirred for 2 h then the solvent was removed under reduced pressure and the residue dried in vacuo to give tert-butyl 4-[(3-hydroxy-2,2-dimethylpropanoyl)amino]cyclohexylcarbamate hydrochloride (305 mg) as a hygroscopic foam, as a ca. 4:1 mixture of diastereoisomers.

Provenance & Evidence