Hydrochloric Acid → HCID 21877198, compound

HRID 724289Notes

Reaction equation

HRID 724289 reaction equation
[ClH:1].[OH:2][CH2:3][C:4]([CH3:23])([CH3:22])[C:5]([NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)=[O:6]>O1CCOCC1>[ClH:1].[OH:2][CH2:3][C:4]([CH3:23])([CH3:22])[C:5]([NH:7][CH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:19])([CH3:18])[CH3:20])[CH2:10][CH2:9]1)=[O:6]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21877153HCID 21877153, compound

Product 1

HCID 21877198HCID 21877198, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4M Hydrochloric acid in dioxan (13 ml, 52 mmol) was added to a solution of the more polar diastereoisomer of tert-butyl 4-[(3-hydroxy-2,2-dimethylpropanoyl)amino]cyclohexylcarbamate (840 g, 2.67 mmol) in dioxan (5 ml). The mixture was stirred for 2 h then the solvent was removed under reduced pressure and the residue dried in vacuo to give tert-butyl 4-[(3-hydroxy-2,2-dimethylpropanoyl)amino]cyclohexylcarbamate hydrochloride (305 mg) as a hygroscopic foam, as a ca. 4:1 mixture of diastereoisomers.

Workup

  1. customthe solvent was removed under reduced pressure
  2. customthe residue dried in vacuo

Sources & evidence

ORD record
ord-9ec8cda18d6d4682bddf7ad7864183ad
Source dataset
uspto-grants-2006_11
Patent number
US07141586B2

Reaction notes

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