Boron tribromide → HCID 136164946, compound

HRID 724408Notes

Reaction equation

[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:18]2[C:13](=[CH:14][C:15]([C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=3[CH2:26][CH2:27][O:28]C)=[CH:16][CH:17]=2)[NH:12][N:11]=1.B(Br)(Br)Br>CCOC(C)=O>[NH:3]1[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[N:1]=[C:2]1[C:10]1[C:18]2[C:13](=[CH:14][C:15]([C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=3[CH2:26][CH2:27][OH:28])=[CH:16][CH:17]=2)[NH:12][N:11]=1

Participants

Conditions

Temperature: -78 °C

Procedure

3-1H-Benzoimidazol-2-yl-6-(2-(2-methoxyethyl)-4-hydroxyphenyl)-1H-indazole, from Example 24(i), (99 mg, 0.26 mmol) was dissolved in EtOAc (20 mL) and cooled to −78° C. under argon. Boron tribromide was added dropwise, and the reaction was allowed to stir while warming to r.t over 3 h. The solution was diluted with EtOAc (60 mL) and washed with sat NaHCO3 and brine (20 mL each). Organics were dried (Na2SO4) and concentrated in vacuo. Purification by silica gel chromatography (THF) gave 56 mg (59%) of the title compound as a white solid. 1H NMR (300 MHz, DMSO-d6) δ 13.60 (s, 1H), 13.01 (s, 1H), 9.41 (s, 1H), 8.49 (d, 1H, J=8.4 Hz), 7.71 (br s, 1H), 7.51 (br s, 1H), 7.46 (s, 1H), 7.21 (app d, 3H, J=8.1 Hz), 7.08 (d, 1H, J=8.4 Hz), 6.77 (d, 1H, J=2.1 Hz), 6.69 (dd, 1H, J=8.1, 2.1 Hz), 4.57 (br s, 1H), 3.46 (t, 2H, J=7.2 Hz), 2.68 (t, 2H, J=7.2 Hz). MS (ES) [m+H]/z calc'd 371. found 371. [m−H]/z calc'd 369. found 369.

Workup

temperaturewhile warming
washwashed
dry with materialOrganics were dried (Na2SO4)
concentrationconcentrated in vacuo
customPurification by silica gel chromatography (THF)

Sources & evidence

ORD record: ord-7deb0280de7940eeba66480d23a2b5a8
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141587B2

Reaction notes

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