反应详情

温度

75 °C

To mixture of N-methyl-N-(2-methyl-4-fluoro-phenyl)azetidin-3-amine (D56) (110 mg, 0.566 mmol) and triethylamine (0.18 ml, 0.849 mmol) in tetrahydrofuran/methanol (3/1 ml) Methyl 2,5-dichloronicotinate (116.82 mg, 0.566 mmol) was added and the mixture was heated at 75° C. for 12 hours. Solvents were evaporated and the residue was purified by SNAP-Si cartridge (10 g) eluting with cyclohexane/ethyl acetate from 100/0 to 90/10. Collected fractions after solvent evaporation afforded the title compound (D87) (170 mg)

1. additionwas added
2. customSolvents were evaporated
3. customthe residue was purified by SNAP-Si cartridge (10 g)
4. washeluting with cyclohexane/ethyl acetate from 100/0 to 90/10
5. customCollected fractions after solvent evaporation